Description

(S)-2-(2-((tert-Butoxycarbonyl)Amino)Acetamido)-3-Methylbutanoic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amino group and a free carboxylic acid, making it a versatile chiral building block. This compound is critical for the synthesis of complex peptides and peptidomimetics, where its defined stereochemistry ensures the biological activity and structural integrity of the final product. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing protease inhibitors, hormone analogs, and other therapeutic peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of novel peptide-based active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used to construct specific amino acid sequences that mimic natural substrates for enzymes like HIV protease or thrombin.
• Peptidomimetic Research: Serves as a foundational component for creating modified peptides with enhanced stability, bioavailability, and receptor selectivity.
• Bioconjugation & Linker Chemistry: The free carboxylic acid group allows for coupling to other molecules, amines, or solid supports for creating targeted drug conjugates or diagnostic probes.
• Academic & R&D: Employed in medicinal chemistry labs for structure-activity relationship (SAR) studies and exploring new bioactive peptide scaffolds.

Basic Information

Product Name	(S)-2-(2-((tert-Butoxycarbonyl)Amino)Acetamido)-3-Methylbutanoic Acid
CAS No.	28334-73-8
Molecular Formula	C12H22N2O5
Molecular Weight	274.32 g/mol
Synonyms	Boc-Gly-L-Val-OH; Nα-Boc-Nω-Glycyl-L-valine; (S)-2-[(2-{[(2-Methyl-2-propanyl)oxy]carbonyl}amino)acetamido]-3-methylbutanoic acid; Boc-Gly-Val-OH; tert-Butyloxycarbonylglycyl-L-valine; N-Boc-glycyl-L-valine; Boc-Gly-L-Valine; L-Valine, N-[2-[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]-
EINECS	Contact for details

Quality Control

Our (S)-2-(2-((tert-Butoxycarbonyl)Amino)Acetamido)-3-Methylbutanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.