Description

Acetamide, 2,2,2-Trifluoro-n-(1-Phenylethyl)- is a specialized fluorinated acetamide derivative characterized by a trifluoromethyl group and a chiral phenylethyl substituent. This molecular architecture makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for introducing fluorine atoms to modulate the biological activity and physicochemical properties of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel fluorinated drug candidates, potentially for central nervous system (CNS) agents, anti-inflammatory drugs, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the synthesis of advanced, fluorinated pesticides and herbicides, where the trifluoromethyl group can enhance metabolic stability and lipophilicity.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where fluorine incorporation can alter thermal stability and optical properties.
• Chemical Biology Probes: Useful for creating fluorinated analogs of biomolecules to study protein-ligand interactions and metabolic pathways.

Basic Information

Product Name	Acetamide, 2,2,2-Trifluoro-n-(1-Phenylethyl)-
CAS No.	28332-81-2
Molecular Formula	C10H10F3NO
Molecular Weight	217.19 g/mol
Synonyms	N-(1-Phenylethyl)-2,2,2-trifluoroacetamide; α-Methylbenzyltrifluoroacetamide; 2,2,2-Trifluoro-N-(1-phenylethyl)acetamide; 1-Phenylethyltrifluoroacetamide; (RS)-N-(1-Phenylethyl)-2,2,2-trifluoroacetamide; Trifluoroacetic acid (1-phenylethyl)amide; TFAA derivative of α-methylbenzylamine
EINECS	Contact for details

Quality Control

Our Acetamide, 2,2,2-Trifluoro-n-(1-Phenylethyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from techniques such as HPLC, GC, NMR, and chiral analysis. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply for critical research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.