Description

Boc-Thr-Onp is a protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy it enables, where the tert-butyloxycarbonyl (Boc) group safeguards the α-amino function and the p-nitrophenyl (Onp) ester provides an efficient active ester for coupling. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the production of complex peptides, peptide hormones, and investigative new drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the sequential coupling of threonine residues under Boc-chemistry protocols.
• Solution-Phase Peptide Synthesis: Used in the fragment condensation approach for constructing longer or more complex peptide sequences.
• Pharmaceutical Intermediates: Serves as a critical raw material in the synthesis of therapeutic peptides and peptidomimetics.
• Bioconjugation: Employed to introduce threonine motifs into proteins, antibodies, or other biomolecules for research and diagnostic applications.
• Combinatorial Chemistry: A valuable building block for generating diverse peptide libraries used in drug discovery and high-throughput screening.
• Academic & Industrial R&D: Used in research laboratories for investigating peptide structure, function, and novel synthetic methodologies.

Basic Information

Product Name	Boc-Thr-Onp
CAS No.	28307-08-6
Molecular Formula	C₁₅H₂₀N₂O₇
Molecular Weight	340.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-benzyl-L-threonine p-nitrophenyl ester; Boc-O-benzyl-L-threonine p-nitrophenyl ester; Boc-Thr(Bzl)-ONp; tert-Butyloxycarbonyl-O-benzylthreonine p-nitrophenyl ester; N-Boc-O-benzylthreonine 4-nitrophenyl ester; (2S,3R)-3-[(Benzyloxy)methyl]-2-[(tert-butoxycarbonyl)amino]butanoic acid 4-nitrophenyl ester; Boc-L-Thr(Bzl)-ONp; Boc-Thr(OBzl)-ONp
EINECS	Contact for details

Quality Control

Our Boc-Thr-Onp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.