Description

Z-Gln(Dod)-Oh is a protected amino acid derivative, specifically N-Carbobenzyloxy-L-glutamine with a side-chain tert-butyl ester protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc/t-Bu chemistry building block for the incorporation of glutamine residues into peptide chains.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates for therapeutic areas such as oncology, metabolic disorders, and neurology.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for antibody-drug conjugates (ADCs) or diagnostic probes.
• Biochemical Research: Production of custom peptides for studying protein-protein interactions, enzyme substrates, or receptor ligands.
• Combinatorial Chemistry: A key component in libraries for high-throughput screening to identify bioactive compounds.

Basic Information

Product Name	Z-Gln(Dod)-Oh
CAS No.	28252-49-5
Molecular Formula	C₂₀H₂₈N₂O₇
Molecular Weight	408.45 g/mol
Synonyms	N-Carbobenzyloxy-L-glutamine γ-tert-butyl ester; Z-L-Glutamine γ-tert-butyl ester; Z-Gln-OtBu; Z-Glutamine-γ-t-butyl ester; Nα-Z-L-glutamine γ-tert-butyl ester; N-Cbz-L-glutamine γ-tert-butyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-5-((tert-butoxy)carbonyl)pentanoic acid; Nα-Carbobenzyloxy-L-glutamine γ-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Z-Gln(Dod)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.