Description

3-Bromo-5-Fluoro-2-Hydroxybenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and a nitrile group ortho to a phenol, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. Its high purity and reliable supply are essential for driving innovation in drug discovery and crop protection agent development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the bromo and fluoro substituents can enhance binding affinity and environmental persistence.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands in transition metal catalysis or as a component in organocatalysts.
• Material Science Research: Employed in the synthesis of functionalized monomers or additives for advanced polymers and liquid crystals.
• Chemical Biology Probes: Useful for constructing molecular probes and tags due to its reactive phenolic and nitrile groups, which can be further derivatized.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom synthesis houses serving the life sciences sector.

Basic Information

Item	Details
Product Name	3-Bromo-5-Fluoro-2-Hydroxybenzonitrile
CAS No.	28165-66-4
Molecular Formula	C7H3BrFNO
Molecular Weight	216.01 g/mol
Synonyms	2-Hydroxy-3-bromo-5-fluorobenzonitrile; 3-Bromo-5-fluoro-2-hydroxybenzonitrile; 5-Fluoro-3-bromo-2-hydroxybenzonitrile; 2-Cyano-6-bromo-4-fluorophenol; Benzonitrile, 3-bromo-5-fluoro-2-hydroxy-; 3-Bromo-5-fluorosalicylonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Fluoro-2-Hydroxybenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.