Description

Z-Thr-Oet CAS NO 28130-04-3 is a protected derivative of the amino acid threonine, specifically the Z-protected ethyl ester. This compound is a crucial building block in peptide synthesis, offering a protected carboxyl group and a free hydroxyl group on the side chain for selective chemical manipulation. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing specific peptide sequences.
• Pharmaceutical Research & Development: Serves as a critical raw material in the discovery and development of peptide-based therapeutics and diagnostics.
• Bioconjugation Chemistry: The free hydroxyl group allows for site-specific modification and labeling of peptides.
• Academic Research: Employed in biochemistry and organic chemistry laboratories for studying peptide structure, function, and synthesis methodologies.
• Production of Custom Peptides: Essential for contract research organizations (CROs) and CDMOs manufacturing bespoke peptide sequences for clients.

Basic Information

Product Name	Z-Thr-Oet
CAS No.	28130-04-3
Molecular Formula	C₁₄H₁₉NO₅
Molecular Weight	281.30 g/mol
Synonyms	N-Carbobenzyloxy-L-threonine ethyl ester; Z-L-Threonine ethyl ester; N-(Benzyloxycarbonyl)-L-threonine ethyl ester; (2S,3R)-2-[[(Benzyloxy)carbonyl]amino]-3-hydroxybutanoic acid ethyl ester; L-Threonine, N-[(phenylmethoxy)carbonyl]-, ethyl ester; CBZ-L-Threonine ethyl ester; Benzyloxycarbonyl-L-threonine ethyl ester; Z-Thr-OEt
EINECS	Contact for details

Quality Control

Our Z-Thr-Oet is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in methanol)
Melting Point	78°C - 82°C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.