Description

2-(4-Bromophenyl)-3-Hydroxyacrylonitrile is a versatile brominated aromatic intermediate featuring both a nitrile and a hydroxyl group on an acrylonitrile backbone. This unique structure makes it a valuable synthon for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists for applications in heterocyclic synthesis and as a building block for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the bromophenyl moiety for bioactivity.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals due to its rigid aromatic core and functional groups.
• Organic Synthesis Reagent: Employed in Michael addition reactions, cyclization processes, and as a precursor for various heterocycles like pyrazoles and isoxazoles.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological pathways and protein interactions.

Basic Information

Product Name	2-(4-Bromophenyl)-3-Hydroxyacrylonitrile
CAS No.	27956-41-8
Molecular Formula	C9H6BrNO
Molecular Weight	224.05 g/mol
Synonyms	3-Hydroxy-2-(4-bromophenyl)acrylonitrile; (2E)-3-Hydroxy-2-(4-bromophenyl)prop-2-enenitrile; 2-(4-Bromophenyl)-3-hydroxy-2-propenenitrile; 4-Bromobenzal cyanohydrin; β-Hydroxy-4-bromocinnamonitrile; (E)-2-(4-Bromophenyl)-3-hydroxyacrylonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Bromophenyl)-3-Hydroxyacrylonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.