Description

(6R,7R)-3-(Acetyloxymethyl)-7-[(2-Acetyloxy-2-Phenyl-Acetyl)Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a key pharmaceutical intermediate, specifically a protected derivative of the cephalosporin nucleus. This compound is of critical importance for the synthesis of advanced β-lactam antibiotics, offering a versatile building block for research and production. It is essential for pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on developing and producing next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for cephalosporin-class antibiotics.
• Antibiotic Research & Development: Used in medicinal chemistry for the design, modification, and structure-activity relationship (SAR) studies of new β-lactam compounds.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for established cephalosporin drugs.
• Reference Standard: Functions as a high-purity analytical standard for quality control and regulatory compliance testing in pharmaceutical production.
• Custom Synthesis: Acts as a starting material for the custom synthesis of novel, patent-protected cephalosporin derivatives.
• Biochemical Studies: Utilized in research investigating the mechanism of action and bacterial resistance to β-lactam antibiotics.

Basic Information

Product Name	(6R,7R)-3-(Acetyloxymethyl)-7-[(2-Acetyloxy-2-Phenyl-Acetyl)Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	27910-29-8
Molecular Formula	C22H22N2O9S
Molecular Weight	490.48 g/mol
Synonyms	7-ACA Diacetate Ester; 7-[(2-Acetoxy-2-phenylacetyl)amino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-ADCA; Cephalosporanic Acid Derivative; 7-Aminocephalosporanic Acid Protected Ester; 3-Acetoxymethyl-7-(2-phenyl-2-acetoxyacetamido)-3-cephem-4-carboxylic Acid; 7β-Phenylmalonylamido-3-acetoxymethyl-3-cephem-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (6R,7R)-3-(Acetyloxymethyl)-7-[(2-Acetyloxy-2-Phenyl-Acetyl)Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and stereochemical integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.