Description

Adrenaline Impurity CAS NO 27827-15-2 is a high-purity reference standard used for analytical and research purposes. This compound is critical for ensuring the quality, safety, and efficacy of adrenaline (epinephrine) pharmaceutical products by serving as a key marker in impurity profiling. It is an essential material for pharmaceutical R&D laboratories, quality control (QC) units, and regulatory affairs departments. Its use is fundamental in method development, validation, and compliance with stringent pharmacopeial guidelines.

Application

• As a certified reference standard for the identification and quantification of impurities in adrenaline (epinephrine) Active Pharmaceutical Ingredients (APIs) and finished drug products.
• For analytical method development and validation (e.g., HPLC, UPLC, GC) in pharmaceutical quality control laboratories.
• In pharmacopeial testing to comply with USP, EP, BP, and other international monographs for adrenaline.
• As a critical component in stability studies to monitor degradation pathways and establish shelf-life for adrenaline-based formulations.
• For regulatory submissions (e.g., ANDA, NDA) to demonstrate comprehensive impurity characterization and control.
• In academic and industrial research focused on the synthesis, metabolism, and degradation chemistry of catecholamines.

Basic Information

Product Name	Adrenaline Impurity
CAS No.	27827-15-2
Molecular Formula	C9H11NO3
Molecular Weight	181.19 g/mol
Synonyms	Adrenalone; 3',4'-Dihydroxy-2-(methylamino)acetophenone; Epinephrine Impurity; Epinephrine Related Compound; Ketonoradrenaline; Methylaminoacetopyrocatechol; Stryphnon; Adrenone; 1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethanone
EINECS	Contact for details

Quality Control

Every batch of our Adrenaline Impurity is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a reference standard, including chromatographic purity and structural confirmation. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity (typically ≥95% by HPLC), and impurity profile. Our quality commitment aligns with the standards expected for pharmaceutical impurity standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity: ≤ 1.0% Total impurities: ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.