Description

Sodium (6R-Trans)-3-[(Acetyloxy)Methyl]-7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is a key sodium salt derivative of a cephalosporin nucleus, serving as a critical advanced intermediate in the synthesis of modern β-lactam antibiotics. Its precise stereochemistry and high purity are essential for ensuring the efficacy and safety of the final active pharmaceutical ingredients (APIs). This compound is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of semi-synthetic cephalosporin antibiotics.

Application

• Pharmaceutical Intermediate: Primary use as a high-value building block in the multi-step synthesis of third and fourth-generation cephalosporin antibiotics.
• API Synthesis: Crucial precursor in the manufacturing of active pharmaceutical ingredients such as Cefotaxime, Ceftriaxone, and other related cephalosporin drugs.
• Research & Development: Used in pharmaceutical R&D for exploring new antibiotic derivatives, structure-activity relationship (SAR) studies, and process optimization.
• Process Chemistry: Employed in scale-up and pilot plant studies for developing efficient and cost-effective commercial synthesis routes.
• Reference Standard: Serves as a chromatographic reference standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	Sodium (6R-Trans)-3-[(Acetyloxy)Methyl]-7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
CAS No.	27795-22-8
Molecular Formula	C11H12N3NaO6S
Molecular Weight	329.28 g/mol
Synonyms	(6R,7R)-7-Amino-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt; 7-ACA Sodium Salt (acetylated); Sodium 7-Aminocephalosporanic Acid Acetate Ester; 7-ACA O-Acetate Sodium Salt; Cephalosporin 7-ACA Derivative Sodium Salt; Sodium 3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-ADCA Intermediate Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium (6R-Trans)-3-[(Acetyloxy)Methyl]-7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity pharmaceutical intermediate standards, with typical purity exceeding 98.5% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.