Description

(Pivaloyloxy)Methyl [6R-[6Alpha,7Beta(R*)]]-7-(2-Amino-2-Phenylacetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is a key pharmaceutical intermediate, specifically a pivaloyloxymethyl (POM) ester prodrug derivative of a cephalosporin antibiotic. This compound is critical for enhancing the bioavailability and stability of the active pharmaceutical ingredient (API) during formulation and storage. It is primarily utilized by manufacturers in the pharmaceutical industry for the synthesis of advanced antibiotic drugs, ensuring high-purity inputs for regulated production processes.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of specific cephalosporin-class antibiotics.
• Prodrug Synthesis: Used to create pivaloyloxymethyl (POM) ester prodrugs, which improve oral absorption and metabolic stability of the parent drug molecule.
• Antibiotic API Manufacturing: An essential raw material in the multi-step production of potent β-lactam antibiotics for human and veterinary use.
• Research & Development: Employed in pharmaceutical R&D labs for developing new antibiotic formulations and studying structure-activity relationships (SAR).
• GMP Production: Supplied for use in Good Manufacturing Practice (GMP)-compliant facilities for the production of finished dosage forms.

Basic Information

Product Name	(Pivaloyloxy)Methyl [6R-[6Alpha,7Beta(R*)]]-7-(2-Amino-2-Phenylacetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride
CAS No.	27726-31-4
Molecular Formula	C24H30ClN3O6S
Molecular Weight	524.03 g/mol
Synonyms	Cefetamet Pivoxil Hydrochloride; Cefetamet Pivoxil HCl; (6R,7R)-7-[(2R)-2-Amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester, hydrochloride; Ro 15-8075; CI-1188; Cefetamet Pivaloyloxymethyl Ester Hydrochloride; POM-Cefetamet Hydrochloride
EINECS	Contact for details

Quality Control

Our (Pivaloyloxy)Methyl [6R-[6Alpha,7Beta(R*)]]-7-(2-Amino-2-Phenylacetamido)-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate Monohydrochloride is produced and tested under a rigorous quality management system. Each batch is analyzed to meet stringent specifications relevant for pharmaceutical intermediates, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing results from advanced analytical techniques such as HPLC, NMR, and mass spectrometry to ensure compliance with customer and regulatory expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.