Description

Trimethoprim n-Oxide 3 is a chemically modified derivative of the established antibiotic Trimethoprim, characterized by the oxidation of its nitrogen atom. This modification is crucial for advanced pharmaceutical research, particularly in the study of drug metabolism, prodrug development, and the synthesis of novel active pharmaceutical ingredients (APIs). It serves as a vital high-purity intermediate for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require precise chemical tools for antibiotic development and metabolic pathway investigation.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel antibiotic compounds and prodrugs.
• Metabolite Reference Standard: Used as an analytical standard in pharmacokinetic and drug metabolism studies to identify and quantify oxidative metabolites.
• Biochemical Research: Employed in enzymatic studies to investigate the mechanisms of bacterial dihydrofolate reductase inhibition and resistance.
• Process Chemistry: Serves as a precursor in the development and optimization of synthetic routes for complex pharmaceutical molecules.
• Quality Control: Utilized as a certified reference material (CRM) for impurity profiling and assay validation of Trimethoprim-based drug substances.

Basic Information

Product Name	Trimethoprim n-Oxide 3
CAS No.	27653-67-4
Molecular Formula	C14H18N4O4
Molecular Weight	306.32 g/mol
Synonyms	2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 1-Oxide; 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine 1-Oxide; Trimethoprim 1-Oxide; Trimethoprim N-Oxide; TMP N-Oxide; NSC 329860; Wy-2445
EINECS	Contact for details

Quality Control

Our Trimethoprim n-Oxide 3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.