Description

1-Fluoro-2-Methoxynaphthalene is a high-purity fluorinated naphthalene derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and methoxy substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for display technologies.
• Dye & Pigment Manufacturing: Acts as an intermediate for creating specialized fluorinated dyes and pigments with improved lightfastness and color properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory synthesis of novel chemical entities.

Basic Information

Product Name	1-Fluoro-2-Methoxynaphthalene
CAS No.	27602-71-7
Molecular Formula	C₁₁H₉FO
Molecular Weight	176.19 g/mol
Synonyms	2-Methoxy-1-fluoronaphthalene; 1-Fluoro-2-naphthyl methyl ether; 1-Fluoro-2-methoxynaphthalene; 27602-71-7; NSC 406903; 2-Fluoromethoxynaphthalene; Fluoromethoxynaphthalene
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-Methoxynaphthalene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.