Description

Proline, 1-Formyl-4-Hydroxy-, L- (8Ci) CAS NO 27585-28-0 is a chemically modified derivative of the amino acid L-proline, featuring both formyl and hydroxy functional groups. This specific functionalization makes it a valuable chiral building block and intermediate for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and industrial R&D departments focused on developing novel peptides, enzyme inhibitors, and other bioactive compounds. The compound's defined stereochemistry and reactive sites enable precise molecular construction in complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapeutics.
• Peptide Chemistry: Used in the synthesis of modified peptides and peptidomimetics, where the formyl and hydroxy groups can be used for further conjugation or to influence peptide conformation and bioactivity.
• Biochemical Research: Employed as a substrate or inhibitor analog in enzymatic studies to investigate reaction mechanisms, particularly those involving proline-specific enzymes.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in asymmetric catalytic reactions to induce stereoselectivity in the formation of new carbon-carbon or carbon-heteroatom bonds.
• Agrochemical Development: Investigated as a potential intermediate for creating novel, biologically active compounds in crop protection and plant growth regulation research.
• Material Science: Explored for the synthesis of functionalized polymers or dendrimers with specific molecular recognition properties.

Basic Information

Product Name	Proline, 1-Formyl-4-Hydroxy-, L- (8Ci)
CAS No.	27585-28-0
Molecular Formula	C6H9NO4
Molecular Weight	159.14 g/mol
Synonyms	L-1-Formyl-4-hydroxyproline; (2S,4R)-1-Formyl-4-hydroxypyrrolidine-2-carboxylic acid; 4-Hydroxy-L-proline, 1-formyl-; 1-Formyl-4-hydroxy-L-proline; 4-Hydroxy-1-formyl-L-proline; 1-Formyl-trans-4-hydroxy-L-proline; trans-4-Hydroxy-1-formyl-L-proline; 1-Formyl-4-hydroxyproline
EINECS	Contact for details

Quality Control

Our Proline, 1-Formyl-4-Hydroxy-, L- (8Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.