Description

Estrone β-D-Glucuronide Triacetate Methyl Ester CAS NO 27537-72-0 is a chemically modified derivative of estrone, specifically designed as a stable analytical reference standard. This compound is of critical importance for research and quality control in endocrinology and analytical chemistry. It is primarily needed by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting hormone metabolism studies.

Application

• Analytical Reference Standard: Used as a primary standard for the quantitative analysis of estrogen metabolites via LC-MS/MS and HPLC in clinical and research settings.
• Biochemical Research: Serves as a key intermediate or probe in studying the glucuronidation pathways of steroid hormones and their pharmacokinetics.
• Diagnostic Development: Essential for the calibration and validation of immunoassays and other diagnostic tests designed to measure estrone glucuronide levels in biological samples.
• Pharmaceutical Impurity Profiling: Employed as a known impurity or metabolite standard in the quality control of steroid-based pharmaceutical products.
• Metabolite Synthesis: Acts as a protected synthetic precursor for the preparation of other estrone conjugates and related biochemical tools.

Basic Information

Product Name	Estrone β-D-Glucuronide Triacetate Methyl Ester
CAS No.	27537-72-0
Molecular Formula	C34H42O13
Molecular Weight	682.70 g/mol
Synonyms	Estrone 3-Glucuronide Triacetate Methyl Ester; Estrone-3-D-glucopyranosiduronic Acid Triacetate Methyl Ester; Methyl (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-[(1S,3aS,3bR,9bS,11aS)-11a-methyl-1,2,3,3a,3b,4,5,9b,10,11-decahydro-7H-cyclopenta[a]phenanthren-1-yl]oxyoxane-2-carboxylate; Estrone Glucuronide Triacetate Methyl Ester; E1-3G Triacetate Methyl Ester
EINECS	Contact for details

Quality Control

Our Estrone β-D-Glucuronide Triacetate Methyl Ester is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assessment and structural confirmation, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.