Description

10-Hydroxy Protriptyline is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant protriptyline. This compound matters for its critical role in drug metabolism studies, analytical reference standard preparation, and the research and development of new therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of high-purity reference materials for applications in bioanalysis and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of protriptyline and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Serves as a critical metabolite standard in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the biotransformation pathways of protriptyline.
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS/MS, and GC-MS methods for therapeutic drug monitoring and forensic toxicology.
• Impurity Profiling: Acts as a specified impurity standard in the quality control of protriptyline active pharmaceutical ingredient (API) to ensure product safety and compliance with ICH guidelines.
• Biochemical Research: Utilized in in-vitro studies to investigate the pharmacological activity and receptor binding profiles of protriptyline metabolites.

Basic Information

Product Name	10-Hydroxy Protriptyline
CAS No.	27462-57-3
Molecular Formula	C19H21NO
Molecular Weight	279.38 g/mol
Synonyms	10-Hydroxyprotriptyline; Protriptyline Metabolite; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol; 10-Hydroxy-N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine; 1-Propanamine, N-methyl-3-(10-hydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-
EINECS	Contact for details

Quality Control

Our 10-Hydroxy Protriptyline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and reference material applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/LC-MS) are provided and traceable to in-house reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.