Description

Azetidine, 3-Methyl-1-(Trifluoroacetyl)- (8Ci) is a specialized heterocyclic building block featuring a reactive azetidine ring functionalized with a trifluoroacetyl group. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists working on novel active ingredients, including protease inhibitors, kinase inhibitors, and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of fluorinated drug candidates, especially in oncology and antiviral research.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where the trifluoromethyl group enhances lipophilicity and environmental stability.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the synthesis of enzyme inhibitors.
• Material Science Research: Investigated as a monomer or precursor for novel fluorinated polymers with unique surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.
• Academic Research: Utilized in methodological studies exploring new ring-opening and functionalization reactions of strained heterocycles.

Basic Information

Product Name	Azetidine, 3-Methyl-1-(Trifluoroacetyl)- (8Ci)
CAS No.	27230-56-4
Molecular Formula	C6H8F3NO
Molecular Weight	167.13 g/mol
Synonyms	3-Methyl-1-(trifluoroacetyl)azetidine; 1-(Trifluoroacetyl)-3-methylazetidine; 3-Methylazetidine-1-carbotrifluoride; N-(Trifluoroacetyl)-3-methylazetidine; 3-Methyl-1-azetidinecarboxylic acid trifluoromethyl ester; 3-Methylazetidine, 1-(trifluoroacetyl)-; 1-Trifluoroacetyl-3-methylazetidine
EINECS	Contact for details

Quality Control

Our Azetidine, 3-Methyl-1-(Trifluoroacetyl)- (8Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. For customers with specific regulatory needs, we can support documentation for cGMP and ISO compliant applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This compound is compatible with strong acids and organic solvents but should be kept separate from strong bases and oxidizing agents. Keep container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.