Description

Z-D-Ala-Osu is a protected amino acid derivative, specifically the N-benzyloxycarbonyl (Z) protected D-alanine active ester with N-hydroxysuccinimide (Osu). This compound is a crucial building block in peptide synthesis, offering high reactivity and selectivity for coupling reactions under mild conditions. It is primarily utilized by research institutions and pharmaceutical manufacturers for the production of custom peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the efficient and racemization-free incorporation of D-alanine into peptide chains.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins in solution, particularly where D-amino acids are required.
• Pharmaceutical Intermediate: Serves as a critical intermediate in the development and manufacturing of peptide-based therapeutics and diagnostic agents.
• Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules with peptides or other functional groups.
• Research & Development: Essential for academic and industrial R&D in medicinal chemistry, biochemistry, and structural biology for creating novel peptide analogs.
• Production of Peptidomimetics: Used to synthesize molecules that mimic the structure and function of natural peptides with improved stability or bioavailability.

Basic Information

Product Name	Z-D-Ala-Osu
CAS No.	27167-53-9
Molecular Formula	C15H16N2O6
Molecular Weight	320.30 g/mol
Synonyms	N-Cbz-D-alanine N-hydroxysuccinimide ester; N-(Benzyloxycarbonyl)-D-alanine N-succinimidyl ester; Z-D-Ala-OSu; D-Alanine, N-[(phenylmethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester; Cbz-D-Ala-OSu; N-Carbobenzoxy-D-alanine N-hydroxysuccinimide ester; Nα-Cbz-D-alanine N-hydroxysuccinimide ester; NSC 334381
EINECS	Contact for details

Quality Control

Our Z-D-Ala-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm D-configuration, and identity verification. Certificates of Analysis (COA) with detailed specifications are provided to ensure the material meets the stringent requirements for pharmaceutical and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]	Specified range
Melting Point	Specified range
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.