Description

Cefazolin Sodium Salt CAS NO 27164-46-1 is a first-generation cephalosporin antibiotic formulated as a sodium salt for enhanced stability and solubility. This compound is a critical active pharmaceutical ingredient (API) valued for its broad-spectrum bactericidal activity against Gram-positive and some Gram-negative bacteria. It is essential for manufacturers in the pharmaceutical industry producing sterile injectable formulations for hospital and clinical use.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of sterile injectable antibiotic preparations.
• Hospital Formulations: Production of vials and infusion bags for the treatment of skin, respiratory, urinary tract, and surgical site infections.
• Prophylactic Use: Key component in pre- and post-operative antibiotic regimens to prevent surgical infections.
• Veterinary Medicine: Used in the development of antibiotic treatments for bacterial infections in animals.
• Research & Development: Serves as a reference standard and building block in microbiological and pharmacological research.
• Bulk Drug Substance: Supplied to compounding pharmacies and large-scale contract manufacturing organizations (CMOs).

Basic Information

Product Name	Cefazolin Sodium Salt
CAS No.	27164-46-1
Molecular Formula	C14H13N8NaO4S3
Molecular Weight	476.50 g/mol
Synonyms	Cefazolin Sodium; Cephazolin Sodium; Ancef Sodium; Kefzol Sodium; Zolicef Sodium; 3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; Sodium (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
EINECS	Contact for details

Quality Control

Our Cefazolin Sodium Salt is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure compliance with major pharmacopoeial standards such as USP, EP, and JP. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring it meets the stringent requirements for pharmaceutical API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (10% solution)	4.0 - 6.0
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.