Description

Sodium (6R-Trans)-3-(Acetoxymethyl)-8-Oxo-7-(1H-Tetrazol-1-Ylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is a high-purity, semi-synthetic β-lactam antibiotic intermediate of significant importance in modern pharmaceutical manufacturing. This compound serves as a critical building block in the synthesis of advanced cephalosporin antibiotics, offering a key structural moiety that influences antibacterial potency and spectrum. It is primarily required by pharmaceutical R&D laboratories and API (Active Pharmaceutical Ingredient) producers focused on developing next-generation anti-infective therapies to combat resistant bacterial strains.

Application

• Pharmaceutical Intermediate: A key precursor in the chemical synthesis of advanced third and fourth-generation cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of bulk antibiotic substances for final dosage forms like injectables.
• Research & Development: Employed in medicinal chemistry for designing and testing novel β-lactam compounds with improved efficacy.
• Process Chemistry: Serves as a standard or reference material for scaling up and optimizing antibiotic synthesis pathways.
• Antibacterial Agent Synthesis: Fundamental for constructing molecules targeting a broad spectrum of Gram-positive and Gram-negative bacteria.

Basic Information

Product Name	Sodium (6R-Trans)-3-(Acetoxymethyl)-8-Oxo-7-(1H-Tetrazol-1-Ylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
CAS No.	27164-45-0
Molecular Formula	C16H15N6NaO6S
Molecular Weight	434.38 g/mol
Synonyms	Sodium Cefazolin Impurity; Cefazolin Sodium EP Impurity C; (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Sodium Salt; Sodium 3-(Acetoxymethyl)-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Cefazolin Related Compound C Sodium Salt; 7-(1H-Tetrazol-1-ylacetamido)cephalosporanic Acid Sodium Salt Derivative; Antibiotic Intermediate 27164-45-0
EINECS	Contact for details

Quality Control

Our Sodium (6R-Trans)-3-(Acetoxymethyl)-8-Oxo-7-(1H-Tetrazol-1-Ylacetamido)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is manufactured under strict quality systems suitable for pharmaceutical intermediate use. All batches undergo rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistent quality and traceability. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.