Description

n-Iodoacetamide is a specialized alkylating agent and a key reagent for the selective modification of cysteine residues in proteins and peptides. This compound is essential for biochemical research and pharmaceutical development, offering precise control in protein structure-function studies and proteomics. It is primarily utilized by researchers and manufacturers in the biotechnology, pharmaceutical, and life science sectors for applications ranging from enzyme inhibition to the preparation of bioconjugates.

Application

• Protein Biochemistry: Selective alkylation of cysteine thiol groups to study protein structure, function, and folding.
• Proteomics Research: Used in mass spectrometry-based workflows for labeling and quantifying cysteine-containing peptides.
• Enzyme Inhibition: Acts as an irreversible inhibitor for thiol-dependent enzymes, aiding in mechanistic studies.
• Bioconjugation: Serves as a cross-linking agent or a handle for attaching fluorescent probes, affinity tags, or other molecules to proteins.
• Pharmaceutical Intermediates: Employed in the synthesis of more complex molecules for drug discovery and development.
• Polymer Chemistry: Can be used as a modifier or chain-transfer agent in specific polymerization reactions.

Basic Information

Product Name	n-Iodoacetamide
CAS No.	27059-94-5
Molecular Formula	C2H4INO
Molecular Weight	184.96 g/mol
Synonyms	Iodoacetamide; 2-Iodoacetamide; IAA; Iodoacetic acid amide; Acetamide, 2-iodo-; Iodoethanamide; N-(Iodoacetyl)amine; Iodoacetamide (unlabeled)
EINECS	Contact for details

Quality Control

Our n-Iodoacetamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.