Description

7-(α-Bromoacetamido)Cephalosporanic Acid is a key chemical intermediate in the synthesis of advanced cephalosporin antibiotics. Its value lies in its reactive bromoacetamido side chain, which serves as a crucial handle for further chemical modifications to create potent, broad-spectrum antibacterial agents. This compound is essential for pharmaceutical R&D laboratories and manufacturers focused on developing next-generation antibiotic therapies to combat resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of semi-synthetic cephalosporin antibiotics, including cefazolin and other first-generation derivatives.
• Antibiotic Research & Development: A critical building block for medicinal chemists developing new β-lactam antibiotics with improved efficacy and resistance profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production scale-up of cephalosporin active ingredients for final drug formulation.
• Bioconjugation Studies: The reactive bromoacetyl group can be utilized for protein-antibiotic conjugate research.
• Chemical Reference Standard: Serves as a high-purity standard for quality control and analytical method development in pharmaceutical analysis.

Basic Information

Product Name	7-(α-Bromoacetamido)Cephalosporanic Acid
CAS No.	26973-80-8
Molecular Formula	C14H15BrN4O6S
Molecular Weight	447.26 g/mol
Synonyms	7-ACA Bromoacetamide; 7-Bromoacetamidocephalosporanic Acid; 7-[(Bromoacetyl)amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-ACA-Br; Cephalosporanic Acid, 7-(bromoacetamido)-; 7-(Bromoacetamido)-3-acetoxymethyl-3-cephem-4-carboxylic Acid; 7-ADCA Bromoacetamide Derivative
EINECS	Contact for details

Quality Control

Our 7-(α-Bromoacetamido)Cephalosporanic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.