Description

(4-Pyridylmethyl)Lithium is a highly reactive organolithium reagent featuring a pyridylmethyl functional group. This compound is crucial for introducing the versatile 4-pyridylmethyl moiety into target molecules via nucleophilic addition or metal-halogen exchange reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs). Its utility lies in enabling precise carbon-carbon bond formation in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Development: Used in the synthesis of advanced herbicides and fungicides that require specific pyridine-based structures for activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized nitrogen-containing ligands used in homogeneous catalysis.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs) with tailored properties.
• Fine Chemical and Custom Synthesis: Essential reagent for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Item	Details
Product Name	(4-Pyridylmethyl)Lithium
CAS No.	26954-25-6
Molecular Formula	C6H6LiN
Molecular Weight	99.06 g/mol
Synonyms	4-(Lithiomethyl)pyridine; 4-Pyridylmethyllithium; p-Pyridylmethyllithium; Lithium (4-pyridylmethyl); (4-Pyridinylmethyl)lithium; Pyridin-4-ylmethyllithium; 4-Picolyl lithium
EINECS	Contact for details

Quality Control

Our production of (4-Pyridylmethyl)Lithium adheres to stringent internal quality standards to ensure batch-to-batch consistency and reactivity. Quality is verified through analytical techniques including titration for lithium content and NMR for structural confirmation and purity assessment. A comprehensive Certificate of Analysis (COA) detailing lot-specific results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive and moisture-sensitive (hygroscopic) nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions or as specified for specific formulations. The storage area should be cool, dry, and well-ventilated, away from incompatible materials.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 0.5 M in specified solvent (e.g., THF, Diethyl ether)
Purity (NMR)	≥ 95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.