Description

1-(Naphthylsulphonyl)-5-Oxo-L-Proline is a specialized chiral building block and proline derivative of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and bioactive molecules, particularly those targeting enzymatic pathways. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly protease inhibitors and other enzyme-targeted therapeutics.
• Peptidomimetic Research: Serves as a constrained proline analog in the design and development of peptidomimetics to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Used in the development of chemical probes for studying enzyme function and protein-protein interactions within biological systems.
• Agrochemical Synthesis: An intermediate in the production of advanced, high-performance agrochemicals with specific chiral activity.
• Catalyst and Ligand Development: Employed as a precursor for creating novel chiral catalysts and ligands used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1-(Naphthylsulphonyl)-5-Oxo-L-Proline
CAS No.	26774-80-1
Molecular Formula	C₁₅H₁₃NO₅S
Molecular Weight	319.33 g/mol
Synonyms	5-Oxo-1-[(naphthalen-1-yl)sulfonyl]-L-proline; 1-Naphthalenesulfonyl-5-oxo-L-proline; L-Proline, 1-(1-naphthalenesulfonyl)-5-oxo-; 5-Oxo-1-(1-naphthylsulfonyl)proline; 1-(1-Naphthylsulfonyl)-5-oxoproline; N-1-Naphthylsulfonyl-5-oxo-L-proline; NSC 339586; 5-Oxo-1-(naphthalene-1-sulfonyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Naphthylsulphonyl)-5-Oxo-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.