Description

4,4,4-Trifluoro-2,2-Dimethyl-3-Oxo-Butyric Acid Ethyl Ester is a high-value fluorinated organic building block, specifically an ethyl ester of a trifluoromethyl-substituted β-keto acid. This compound is prized for its unique reactivity profile, serving as a versatile synthon for introducing the trifluoromethyl group into complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, which are known to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF₃ moiety can improve biological activity and environmental persistence.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and electronic materials that require fluorinated segments for specific thermal, chemical, or optical properties.
• Organic Synthesis Reagent: Employed in Claisen condensations, Michael additions, and other carbon-carbon bond-forming reactions to construct complex, fluorinated organic molecules in research settings.
• Chemical Research & Development: Essential for medicinal chemistry programs and process chemistry optimization in both academic and industrial laboratories exploring fluorine chemistry.

Basic Information

Product Name	4,4,4-Trifluoro-2,2-Dimethyl-3-Oxo-Butyric Acid Ethyl Ester
CAS No.	26717-76-0
Molecular Formula	C₈H₁₁F₃O₃
Molecular Weight	212.17 g/mol
Synonyms	Ethyl 4,4,4-Trifluoro-3-oxo-2,2-dimethylbutanoate; Ethyl 4,4,4-Trifluoroacetoacetate, 2,2-Dimethyl; 2,2-Dimethyl-4,4,4-trifluoro-3-oxobutanoic Acid Ethyl Ester; 4,4,4-Trifluoro-2,2-dimethylacetoacetic Acid Ethyl Ester; 3-Oxo-4,4,4-trifluoro-2,2-dimethylbutyric Acid Ethyl Ester; TFAAE Derivative; Trifluoromethyl Dimethyl Keto Ester
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-2,2-Dimethyl-3-Oxo-Butyric Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. This material is compatible with strong alkali and organic solvents; store away from incompatible materials. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.