Description

N4-Benzoylcytosine CAS NO 26661-13-2 is a key cytosine derivative where the N4 nitrogen is protected by a benzoyl group. This modification is critical for its primary role as a versatile building block and protecting group intermediate in the synthesis of nucleosides, nucleotides, and oligonucleotides. It is an essential raw material for pharmaceutical R&D, particularly in the development of antiviral and anticancer agents, as well as for advanced biochemical research.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of modified nucleoside analogs for antiviral and anticancer drug discovery.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase synthesis of DNA and RNA sequences in research and diagnostics.
• Biochemical Research: Used in studies involving nucleic acid chemistry, enzyme mechanisms, and as a standard for analytical methods.
• Protecting Group Chemistry: The benzoyl group provides temporary protection for the exocyclic amine during multi-step synthetic routes.
• Agrochemical Research: Potential intermediate in the development of novel pesticides or plant growth regulators based on nucleoside chemistry.
• Academic & Industrial R&D: Fundamental building block for exploring new chemical entities in medicinal and synthetic chemistry laboratories worldwide.

Basic Information

Product Name	N4-Benzoylcytosine
CAS No.	26661-13-2
Molecular Formula	C11H9N3O2
Molecular Weight	215.21 g/mol
Synonyms	N-Benzoylcytosine; Cytosine, N-benzoyl-; 4-Benzoylamino-2-hydroxypyrimidine; 2(1H)-Pyrimidinone, 4-(benzoylamino)-; 4-N-Benzoylcytosine; Bz-Cytosine; N4-Bz-cytosine; 4-Amino-2-oxo-1,2-dihydropyrimidine-1-benzoic acid
EINECS	Contact for details

Quality Control

Our N4-Benzoylcytosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.