Description

N,N'-Bis(Trifluoroacetyl) L-Cystine Dimethyl Ester is a high-purity, protected derivative of the amino acid L-cystine, specifically designed for advanced organic synthesis and pharmaceutical research. This compound is a critical building block for the controlled introduction of disulfide bonds and cysteine functionalities into complex molecules, enabling precise molecular engineering. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis sectors for developing novel therapeutics and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs) requiring protected cysteine or disulfide linkages.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected form of cystine to prevent unwanted side reactions during coupling steps.
• Bioconjugation & Protein Engineering: Serves as a reagent for introducing stable, chemically defined cross-links or labels into proteins and antibodies for research and diagnostic applications.
• Chemical Biology Research: Employed in the study of redox biology, protein folding, and enzyme mechanisms where controlled disulfide bond formation is essential.
• Reference Standard: Used as a certified reference material (CRM) or analytical standard in quality control laboratories for method development and validation.
• Material Science: Potential applications in creating functionalized polymers or surfaces with specific thiol-reactive properties.

Basic Information

Product Name	N,N'-Bis(Trifluoroacetyl) L-Cystine Dimethyl Ester
CAS No.	26527-24-2
Molecular Formula	C12H12F6N2O6S2
Molecular Weight	458.35 g/mol
Synonyms	L-Cystine, N,N'-bis(trifluoroacetyl)-, dimethyl ester; Bis(trifluoroacetyl)cystine dimethyl ester; Dimethyl N,N'-bis(trifluoroacetyl)-L-cystinate; N,N'-Di(trifluoroacetyl)-L-cystine dimethyl ester; L-Cystine dimethyl ester tetrafluoride derivative; (2R,2'R)-3,3'-Disulfanediylbis(2-[(2,2,2-trifluoroacetyl)amino]propanoic acid) dimethyl ester; Protected L-Cystine DM ester; TFA-L-Cystine(OMe)2
EINECS	Contact for details

Quality Control

Our N,N'-Bis(Trifluoroacetyl) L-Cystine Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed batch-specific results, ensuring traceability and compliance with research and cGMP-grade requirements where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.