Description

D-Carglumic Acid (30 Mg) (n-Carbamoyl-D-Glutamic Acid) is a high-purity, enantiomerically pure pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critical for its role as a structural analog of N-acetylglutamate, serving as an essential activator for carbamoyl phosphate synthetase 1 in the urea cycle. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for inborn errors of metabolism, specifically N-acetylglutamate synthase (NAGS) deficiency. Our product is supplied with stringent quality control to ensure reliability for sensitive formulation and research applications.

Application

• Pharmaceutical API: Core active ingredient in prescription medications for the treatment of hyperammonemia due to N-acetylglutamate synthase (NAGS) deficiency.
• Metabolic Disorder Research: Key reference standard and tool in biochemical research focused on the urea cycle and related metabolic pathways.
• Preclinical & Clinical Development: Used in the formulation of drug candidates during non-clinical studies and clinical trials for metabolic diseases.
• Diagnostic Agent Manufacturing: Component in the production of specialized diagnostic kits and reagents for assessing liver function and ammonia metabolism.
• Biochemical Synthesis: Serves as a chiral building block or intermediate in the synthesis of more complex bioactive molecules and peptides.

Basic Information

Product Name	D-Carglumic Acid (30 Mg) (n-Carbamoyl-D-Glutamic Acid)
CAS No.	26117-15-7
Molecular Formula	C6H10N2O5
Molecular Weight	190.15 g/mol
Synonyms	N-Carbamoyl-D-glutamic Acid; D-Carbamoylglutamic Acid; (2R)-2-(Carbamoylamino)pentanedioic Acid; D-CGA; Carglumic Acid D-isomer; N-Carbamyl-D-glutamic Acid; D-N-Carbamoylglutamate; (R)-2-(Carbamoylamino)glutaric Acid
EINECS	Contact for details

Quality Control

Our D-Carglumic Acid is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical applications, with a focus on chiral purity and low impurity profiles. Certificates of Analysis (COA) are provided, detailing results for assay, enantiomeric excess, related substances, and residual solvents. We adhere to cGMP principles where applicable to ensure supply chain integrity and batch-to-batch consistency for critical end-uses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the original container is kept sealed in a dry environment to prevent degradation or clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.