Description

Loxapine n-Oxide CAS NO 25967-34-4 is a significant pharmaceutical intermediate and metabolite of the antipsychotic agent Loxapine. This compound is of critical importance for research and development in neuropharmacology, serving as a key reference standard and a building block for further chemical synthesis. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on central nervous system (CNS) drug development, quality control, and metabolic studies.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of Loxapine and related antipsychotic compounds.
• Analytical Reference Standard: Used for qualitative and quantitative analysis (e.g., HPLC, LC-MS) in pharmaceutical quality control and method validation.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and activity profile of Loxapine.
• Biochemical Research: Employed in vitro and in vivo studies to investigate dopaminergic and serotonergic receptor interactions.
• Impurity Standard: Used to identify, quantify, and control related substance impurities in Loxapine Active Pharmaceutical Ingredient (API) batches.
• Custom Synthesis: Serves as a starting material for the development of novel analogs and derivatives with potential therapeutic applications.

Basic Information

Product Name	Loxapine n-Oxide
CAS No.	25967-34-4
Molecular Formula	C₁₈H₁₈ClN₃O₂
Molecular Weight	343.81 g/mol
Synonyms	Loxapine N-Oxide; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine 5-oxide; Loxapine 5-Oxide; Loxapine Oxide; 7-Chloro-2-(1-piperazinyl)-4H-benzo[b][1,4]benzoxazepine 4-oxide; Loxapine Metabolite; Loxapine N-Oxide (Major Metabolite); CL-71563
EINECS	Contact for details

Quality Control

Our Loxapine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets high-purity standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.