Description

(R)-Amino-(3-Fluoro-Phenyl)-Acetic Acid CAS NO 25698-44-6 is a high-purity, single-enantiomer chiral building block essential for modern asymmetric synthesis. Its value lies in providing a defined stereocenter for constructing complex molecules with high optical purity, which is critical for biological activity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Asymmetric Catalyst Ligand Precursor: Used to develop chiral ligands for metal-catalyzed reactions, enabling enantioselective C-C and C-N bond formations.
• Peptidomimetic Chemistry: Incorporated into non-natural amino acid sequences to modulate peptide stability, bioavailability, and receptor binding.
• Agrochemical Synthesis: Serves as a building block for chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and for creating libraries of chiral compounds for screening.

Basic Information

Product Name	(R)-Amino-(3-Fluoro-Phenyl)-Acetic Acid
CAS No.	25698-44-6
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	(R)-2-Amino-2-(3-fluorophenyl)acetic acid; D-α-Amino-3-fluorobenzeneacetic acid; (R)-2-Amino-(3-fluorophenyl)ethanoic acid; (R)-3-Fluoro-D-phenylglycine; (R)-α-Amino-3-fluorophenylacetic acid; (R)-(3-Fluorophenyl)glycine; (R)-FPhg-OH
EINECS	Contact for details

Quality Control

Our (R)-Amino-(3-Fluoro-Phenyl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed to exclude moisture. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.