Description

Angiotensin I, Des-Leu(10)- is a specific, truncated analog of the Angiotensin I peptide, where the leucine residue at position 10 has been removed. This modification makes it a critical biochemical tool for studying the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It is primarily utilized by research scientists and pharmaceutical developers in cardiovascular research, enzymology studies, and as a reference standard for assay development and validation.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in studies of angiotensin-converting enzyme (ACE) and other proteases within the renin-angiotensin system.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the discovery and testing of novel antihypertensive drugs.
• Enzymology Assays: Employed in kinetic studies to determine enzyme activity, specificity, and inhibition constants for proteolytic enzymes.
• Diagnostic Reagent Manufacturing: Used in the production of calibrators and controls for diagnostic kits targeting components of the RAS pathway.
• Academic Research: A vital tool for university and institutional labs investigating cardiovascular physiology, peptide metabolism, and hormone regulation.
• Quality Control Standard: Acts as a high-purity reference standard for the quality assurance of related peptide pharmaceuticals and research chemicals.

Basic Information

Product Name	Angiotensin I, Des-Leu(10)-
CAS No.	25673-02-3
Molecular Formula	C61H86N16O13
Molecular Weight	1227.4 g/mol
Synonyms	Angiotensin I (1-9); Des-Leucine10-Angiotensin I; [Des-Leu10]-Angiotensin I; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His; DRVYIHPFH; Angiotensin I Fragment 1-9; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
EINECS	Contact for details

Quality Control

Our Angiotensin I, Des-Leu(10)- is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous in-house quality protocols to guarantee batch-to-batch reproducibility and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.