Description

Boc-His(1-Boc)-Osu CAS NO 25616-02-8 is a protected amino acid derivative, specifically an N-α-Boc and N-τ-Boc protected histidine active ester. This compound matters as a critical building block in solid-phase peptide synthesis (SPPS), offering enhanced stability and controlled reactivity for the selective incorporation of histidine residues. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled, sequential addition of protected histidine during automated or manual peptide chain assembly.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments and small peptides in solution.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: The active ester (Osu) group facilitates efficient coupling to amines, useful for creating peptide-protein conjugates or labeled peptides.
• Research & Development: Essential for academic and industrial research in biochemistry, medicinal chemistry, and proteomics for studying peptide structure and function.
• Custom Peptide Service Providers: A standard raw material for companies offering bespoke peptide synthesis services to the research community.

Basic Information

Product Name	Boc-His(1-Boc)-Osu
CAS No.	25616-02-8
Molecular Formula	C₂₁H₃₂N₄O₈
Molecular Weight	468.50 g/mol
Synonyms	N-α-Boc-N-τ-Boc-L-histidine N-hydroxysuccinimide ester; Boc-His(Boc)-OH N-succinimidyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-((tert-butoxycarbonyl)-1H-imidazol-4-yl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; Boc-L-histidine(Boc)-OSu; N-α-Boc-N-im-Boc-L-histidine active ester; tert-Butyloxycarbonyl-histidine(tert-butyloxycarbonyl)-O-succinimide ester; Boc-His(Boc)-OSu; Boc-His(Boc)-ONSu
EINECS	Contact for details

Quality Control

Our Boc-His(1-Boc)-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for peptide synthesis. Certificates of Analysis (COA) providing detailed specifications for identity, purity (HPLC), and chiral purity are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO; slightly soluble in dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.