Description

(S)-(+)-2-Methylbutyronitrile is a chiral nitrile compound of significant importance in asymmetric synthesis and pharmaceutical manufacturing. Its value lies in its role as a versatile chiral building block for the production of active pharmaceutical ingredients (APIs) and fine chemicals. This high-purity enantiomer is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise stereochemistry is critical for biological activity and process efficiency.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key building block for the synthesis of enantiomerically pure APIs, including potential antiviral and cardiovascular drugs.
• Agrochemical Production: Used in the manufacture of chiral pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Fine Chemical and Flavor & Fragrance Precursor: Serves as a starting material for the synthesis of complex chiral molecules used in specialty chemicals and aroma compounds.
• Ligand and Catalyst Development: Employed in research for developing novel chiral ligands and catalysts used in asymmetric catalysis.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry research.

Basic Information

Product Name	(S)-(+)-2-Methylbutyronitrile
CAS No.	25570-03-0
Molecular Formula	C5H9N
Molecular Weight	83.13 g/mol
Synonyms	(S)-2-Methylbutyronitrile; (S)-(+)-2-Methylbutanenitrile; (S)-2-Methylbutyric acid nitrile; (S)-2-Methylpropyl cyanide; (S)-Sec-butyl cyanide; (S)-1-Cyano-2-methylbutane; (S)-α-Methylbutyronitrile; L-2-Methylbutyronitrile
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Methylbutyronitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, GC, and NMR, to verify identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flames. Containers should be kept tightly sealed when not in use to prevent evaporation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Optical Rotation [α]D20	+15° to +20° (c=1, CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.