Description

2,3,4,5-Tetra-o-Acetyl-D-Ribonitrile is a key protected ribose derivative, serving as a vital chiral building block in organic synthesis. Its value lies in providing a versatile, reactive nitrile handle for constructing complex nucleoside analogs and other bioactive molecules. This high-purity intermediate is essential for pharmaceutical R&D and production, particularly in the development of antiviral and anticancer therapeutics.

Application

• Nucleoside & Nucleotide Synthesis: A critical precursor for the preparation of modified ribonucleosides and their corresponding phosphate analogs.
• Antiviral Drug Development: Used in the research and manufacturing of novel antiviral agents targeting RNA viruses.
• Pharmaceutical Intermediates: Serves as a chiral synthon for constructing complex pharmacologically active compounds.
• Carbocyclic Nucleoside Synthesis: Employed in the synthesis of carbocyclic analogs with enhanced metabolic stability.
• Labeled Compound Production: Useful for introducing isotopic labels (e.g., 13C, 15N) into sugar moieties for metabolic studies.
• Glycochemistry Research: Acts as a starting material for exploring novel glycosylation methodologies and carbohydrate mimetics.

Basic Information

Product Name	2,3,4,5-Tetra-o-Acetyl-D-Ribonitrile
CAS No.	25546-50-3
Molecular Formula	C13H17NO8
Molecular Weight	315.28 g/mol
Synonyms	2,3,4,5-Tetra-O-acetyl-D-ribonitrile; D-Ribonitrile, 2,3,4,5-tetraacetate; Tetra-O-acetyl-D-ribonitrile; 1-O-Acetyl-2,3,4,5-tetra-O-acetyl-D-ribofuranose nitrile; Acetylated D-ribonitrile; D-Ribose nitrile tetraacetate; 2,3,4,5-Tetraacetyl-D-ribonitrile
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetra-o-Acetyl-D-Ribonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.