Description

2-Hydroxy Desipramine Glucuronide Hcl is a key glucuronide metabolite of the tricyclic antidepressant desipramine. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development and ADME (Absorption, Distribution, Metabolism, and Excretion) studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of desipramine and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance mechanisms, and bioavailability of desipramine.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring (TDM) and clinical research.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential toxic metabolites of tricyclic antidepressants.
• Enzyme Reaction Studies: Used as a substrate or reference compound in studies involving UDP-glucuronosyltransferase (UGT) enzymes to understand glucuronidation kinetics.

Basic Information

Product Name	2-Hydroxy Desipramine Glucuronide Hcl
CAS No.	25521-31-7
Molecular Formula	C24H31ClN2O7
Molecular Weight	494.97 g/mol
Synonyms	2-Hydroxydesipramine Glucuronide Hydrochloride; Desipramine, 2-hydroxy-, glucuronide, hydrochloride; 2-HO-Desipramine Glucuronide HCl; 2-Hydroxy-10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine glucuronide hydrochloride; Norzimelidine metabolite glucuronide (related); Desmethylimipramine 2-hydroxy glucuronide HCl
EINECS	Contact for details

Quality Control

Our 2-Hydroxy Desipramine Glucuronide Hcl is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry guidelines for reference standard materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.