Description

n-Tfa-L-Alanine Methyl Ester is a protected amino acid derivative, specifically the methyl ester of N-trifluoroacetyl-L-alanine. This compound serves as a crucial chiral building block in advanced organic synthesis, offering a reactive ester group and a stable trifluoroacetyl protecting group. It is primarily utilized by research institutions and pharmaceutical manufacturers for the synthesis of peptides, peptidomimetics, and other bioactive molecules where precise stereochemistry is essential.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the L-alanine residue with orthogonal protection.
• Bioconjugation & Labeling: Acts as a precursor for creating modified amino acids used in bioconjugation chemistry and probe development.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, protein-protein interactions, and metabolic pathways.
• Asymmetric Synthesis: Serves as a starting material or intermediate in the asymmetric synthesis of complex natural products and fine chemicals.
• Protecting Group Chemistry: Demonstrates utility in multi-step syntheses where the TFA group provides stability under various reaction conditions.

Basic Information

Product Name	n-Tfa-L-Alanine Methyl Ester
CAS No.	25518-39-2
Molecular Formula	C7H10F3NO3
Molecular Weight	213.16 g/mol
Synonyms	N-(Trifluoroacetyl)-L-alanine methyl ester; Methyl (2S)-2-[(trifluoroacetyl)amino]propanoate; L-Alanine, N-(trifluoroacetyl)-, methyl ester; TFA-L-Ala-OMe; Methyl N-trifluoroacetyl-L-alaninate; (S)-Methyl 2-(trifluoroacetamido)propanoate; N-Trifluoroacetyllalanine methyl ester
EINECS	Contact for details

Quality Control

Our n-Tfa-L-Alanine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, specific rotation, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.