Description

Triacetyl Aloe-Emodin (Impurity A) is a chemically modified derivative of aloe-emodin, specifically acetylated at three hydroxyl groups. This compound is of significant importance in the pharmaceutical industry as a well-characterized reference standard and impurity for quality control in drug development and manufacturing. It is primarily needed by analytical laboratories, research institutions, and pharmaceutical companies involved in the synthesis, purification, and regulatory analysis of anthraquinone-based drug substances and herbal products.

Application

• Pharmaceutical Reference Standard: Used as a certified impurity standard (Impurity A) for the identification and quantification of related substances in active pharmaceutical ingredients (APIs) derived from aloe-emodin.
• Analytical Research: Serves as a critical analytical marker in method development and validation for HPLC, UPLC, and LC-MS assays in quality control laboratories.
• Metabolic and Pharmacokinetic Studies: Employed as a metabolite or derivative standard in ADME (Absorption, Distribution, Metabolism, and Excretion) research for anthraquinone compounds.
• Process Chemistry: Acts as an intermediate or a by-product marker during the chemical synthesis and scale-up of related pharmaceutical compounds.
• Herbal Medicine Quality Control: Utilized in the standardization and authentication of herbal extracts containing aloe-emodin to ensure batch-to-batch consistency and purity.

Basic Information

Product Name	Triacetyl Aloe-Emodin (Impurity A)
CAS No.	25395-11-3
Molecular Formula	C23H20O9
Molecular Weight	440.40 g/mol
Synonyms	1,8-Diacetoxy-3-(hydroxymethyl)-6-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-yl acetate; Aloe-Emodin Triacetate; 1,8-Diacetoxy-3-(hydroxymethyl)-6-methoxyanthraquinone-2-yl acetate; 3-(Acetyloxymethyl)-1,8-diacetoxy-6-methoxy-9,10-anthracenedione; Triacetylaloe-emodin; Aloe-emodin triacetyl derivative; Impurity A of Aloe-Emodin
EINECS	Contact for details

Quality Control

Our Triacetyl Aloe-Emodin (Impurity A) is produced under strict quality management systems to ensure high purity and consistency, suitable for use as a reference material. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment, supporting compliance with ICH Q3A/B guidelines for impurities in new drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.