Description

n-Boc-3,5-Dichloroaniline is a protected aniline derivative where the amine group is shielded by a tert-butoxycarbonyl (Boc) group, making it a crucial building block in synthetic organic chemistry. This compound matters because it provides a stable, reactive intermediate for constructing complex molecules, particularly in environments where a free aniline would be incompatible. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of active pharmaceutical ingredients (APIs), advanced intermediates, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the dichloroaniline scaffold is required.
• Peptide Chemistry & Linker: Serves as a protected amine precursor for introducing aniline-containing amino acids or as a component in solid-phase synthesis linkers.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, dyes, and advanced organic materials.
• Cross-Coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to form C-N bonds.
• Academic & Contract Research: Essential reagent in university and CRO laboratories for methodological development and novel compound library generation.

Basic Information

Product Name	n-Boc-3,5-Dichloroaniline
CAS No.	25216-60-8
Molecular Formula	C11H13Cl2NO2
Molecular Weight	262.13 g/mol
Synonyms	1-(tert-Butoxycarbonylamino)-3,5-dichlorobenzene; 3,5-Dichloro-N-(tert-butoxycarbonyl)aniline; tert-Butyl (3,5-dichlorophenyl)carbamate; N-Boc-3,5-dichloroaniline; Boc-3,5-DCA; N-(tert-Butoxycarbonyl)-3,5-dichloroaniline; 3,5-Dichlorophenylcarbamic acid tert-butyl ester; (3,5-Dichlorophenyl)carbamic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-3,5-Dichloroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Under these conditions, the product remains stable for extended periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.