Description

2-Fluorobenzylmethylsulfone is a versatile fluorinated sulfone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the sulfone group adjacent to a fluorinated benzyl moiety, enabling precise molecular construction. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with tailored surface properties and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Fluorobenzylmethylsulfone
CAS No.	25195-45-3
Molecular Formula	C8H9FO2S
Molecular Weight	188.22 g/mol
Synonyms	1-(Fluoromethyl)-2-(methylsulfonyl)benzene; (2-Fluorophenyl)methyl methyl sulfone; α-Fluoro-o-tolyl methyl sulfone; 2-Fluorobenzyl Methyl Sulfone; Methyl (2-fluorobenzyl) sulfone; 2-Fluoro-α-(methylsulfonyl)toluene; o-Fluorobenzylmethylsulfone
EINECS	Contact for details

Quality Control

Our 2-Fluorobenzylmethylsulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances, supporting its use in GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.