Description

Dexamethasone 9,11-Epoxide is a key synthetic intermediate in the production of high-potency corticosteroid pharmaceuticals. This compound is critical for researchers and manufacturers developing and scaling up the synthesis of dexamethasone and its analogs, ensuring precise control over the steroid's molecular structure. It is primarily utilized by the pharmaceutical industry for advanced R&D and active pharmaceutical ingredient (API) manufacturing.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of the anti-inflammatory drug Dexamethasone and related corticosteroid APIs.
• Steroid Chemistry Research: Used in academic and industrial laboratories to study steroid epoxidation reactions and structure-activity relationships (SAR).
• Process Development: Serves as a reference standard and starting material for optimizing synthetic routes and scaling up production in pilot plants.
• Impurity Standard: Employed as a certified reference material (CRM) in analytical laboratories for quality control and impurity profiling of dexamethasone batches.
• Derivative Synthesis: Used to create novel dexamethasone derivatives for pharmacological evaluation and new drug discovery programs.

Basic Information

Product Name	Dexamethasone 9,11-Epoxide
CAS No.	24916-90-3
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	9β,11β-Epoxy-16α-methylpregna-1,4-diene-3,20-dione, 9β,11β-Epoxy-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione, Dexamethasone 9β,11β-Epoxide, 9,11β-Epoxydexamethasone, (9β,11β)-9,11-Epoxy-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Dexamethasone 9,11-Epoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.