Description

Ac-Gly-Osu (N-Acetylglycine N-Hydroxysuccinimide Ester) is a high-purity, reactive biochemical intermediate primarily used as a peptide coupling reagent. This compound is critical for introducing an acetyl-glycine moiety into target molecules under mild conditions, enabling efficient synthesis and modification. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and bioconjugation, where precise and reliable chemical building blocks are required.

Application

• Peptide Synthesis: Key reagent for the efficient coupling of amino acids in solid-phase and solution-phase peptide synthesis.
• Bioconjugation & Labeling: Used to modify proteins, antibodies, and other biomolecules with acetyl-glycine tags or probes for diagnostic and therapeutic applications.
• Proteomics Research: Employed in the preparation of affinity tags, enzyme substrates, and other tools for studying protein structure and function.
• Chemical Biology: Serves as a versatile building block for creating novel chemical entities and libraries for drug discovery screening.
• Intermediate for Fine Chemicals: Acts as a precursor in the multi-step synthesis of more complex pharmaceutical intermediates and active ingredients.

Basic Information

Product Name	Ac-Gly-Osu
CAS No.	24715-24-0
Molecular Formula	C8H10N2O5
Molecular Weight	214.18 g/mol
Synonyms	N-Acetylglycine N-Hydroxysuccinimide Ester; N-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-N-acetylglycine; N-Acetylglycine Hydroxysuccinimide Ester; N-Acetylglycine NHS Ester; N-Hydroxysuccinimide Acetylglycinate; Ac-Gly-OSu; Ac-Glycine-OSu; Ac-Gly-ONSu
EINECS	Contact for details

Quality Control

Our Ac-Gly-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, purity by HPLC, and identification. We adhere to cGMP principles where applicable, supporting its use in research and development applications requiring reliable material quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.