Description

(S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic Acid is a high-value, single-enantiomer trifluoromethylated building block essential for modern synthetic chemistry. Its unique structure, featuring a chiral tertiary alcohol adjacent to a trifluoromethyl group and a carboxylic acid, makes it a critical intermediate for introducing stereochemistry and fluorine into target molecules. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl group to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling highly enantioselective transformations.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials where fluorine incorporation improves chemical resistance, thermal stability, and surface properties.
• Peptidomimetics and Bioisosteres: The acid functionality allows for incorporation into peptide chains, acting as a non-natural amino acid analog to create more stable and potent bioactive compounds.

Basic Information

Product Name	(S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic Acid
CAS No.	24435-45-8
Molecular Formula	C4H5F3O3
Molecular Weight	158.08 g/mol
Synonyms	(S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid; (S)-2-Hydroxy-2-(trifluoromethyl)propionic acid; (S)-α-Hydroxy-α-(trifluoromethyl)propionic acid; (S)-HTPA; L-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic acid; (2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid; (S)-TFMPA
EINECS	Contact for details

Quality Control

Our (S)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity, critical for chiral applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity (HPLC), chemical purity, and identity confirmation. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply for your development and scale-up needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.