Description

Apamin is a potent neurotoxin and a major component of bee venom, characterized by its specific and high-affinity blockade of small-conductance calcium-activated potassium (SK) channels. This unique mechanism of action makes it an invaluable research-grade biochemical tool for neuroscience, pharmacology, and ion channel studies. It is primarily utilized by academic research institutions, pharmaceutical R&D departments, and biotechnology companies investigating neuronal excitability, synaptic transmission, and cardiac electrophysiology.

Application

• Neuroscience Research: As a selective SK channel blocker to study the role of these channels in neuronal afterhyperpolarization, synaptic plasticity, and firing patterns.
• Pharmacological Tool: Used in in vitro and ex vivo assays to validate drug candidates targeting SK channels or to probe channel function.
• Cardiovascular Research: Investigation of SK channel involvement in atrial fibrillation and cardiac action potential duration.
• Toxicology Studies: Reference standard for the analysis of bee venom components and related allergic responses.
• Cell Signaling Pathways: Research into calcium signaling cascades and their modulation by potassium efflux.
• Biochemical Standard: For calibration in analytical methods such as HPLC or mass spectrometry within quality control labs.

Basic Information

Product Name	Apamin
CAS No.	24345-16-2
Molecular Formula	C79H131N31O24S4
Molecular Weight	2027.3 g/mol
Synonyms	Apamin (bee venom); Apanin; Apamina; NSC 208777; Bee Venom Peptide Apamin; SK Channel Blocker Apamin; Small-Conductance Calcium-Activated Potassium Channel Inhibitor
EINECS	Contact for details

Quality Control

Our Apamin is produced and tested to meet high-purity standards suitable for advanced research applications. Each batch is accompanied by comprehensive analytical data to ensure identity, purity, and biological activity. Certificates of Analysis (COA) detailing HPLC purity, peptide content, mass spectrometry confirmation, and functional assay data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Confirmed by functional assay (e.g., SK channel blockade)
Single-Charged Mass (MS)	2027.3 ± 2.0 Da

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.