Description

(6R-Trans)-7-Amino-8-Oxo-3-[(1,3,4-Thiadiazol-2-Ylthio)Methyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a sophisticated cephalosporin nucleus derivative, serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its value lies in enabling the production of next-generation β-lactam antibiotics with enhanced efficacy and resistance profiles. This high-purity compound is essential for research institutions and pharmaceutical manufacturers focused on developing novel antibacterial agents and fine-tuning antibiotic structures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced cephalosporin antibiotics.
• Antibacterial Drug Research: Used in R&D for developing new compounds to combat drug-resistant bacterial strains.
• Chemical Synthesis: Serves as a precursor for modifying the β-lactam core to improve pharmacokinetic properties.
• Process Development: Employed in scaling up and optimizing manufacturing routes for final active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Provides a high-purity benchmark for quality control and method validation in antibiotic production.
• Academic Research: Utilized in university and institutional studies exploring novel mechanisms of antibiotic action.

Basic Information

Product Name	(6R-Trans)-7-Amino-8-Oxo-3-[(1,3,4-Thiadiazol-2-Ylthio)Methyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	24209-43-6
Molecular Formula	C11H11N5O3S3
Molecular Weight	373.43 g/mol
Synonyms	7-ACA Thiadiazole Derivative; 7-Aminocephalosporanic Acid Thiadiazolethioether; 3-[(1,3,4-Thiadiazol-2-ylthio)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-Amino-3-(((1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephalosporin C Nucleus Analog; Antibiotic Intermediate 24209-43-6; 7-ACA-(1,3,4-Thiadiazolyl) Thioether
EINECS	Contact for details

Quality Control

Our (6R-Trans)-7-Amino-8-Oxo-3-[(1,3,4-Thiadiazol-2-Ylthio)Methyl]-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.