Description

4-Fluorophenyl Isocyanide is a versatile and highly reactive organic building block characterized by its isocyanide functional group attached to a fluorinated aromatic ring. This compound is crucial for the synthesis of complex heterocycles and functional molecules through multicomponent reactions like the Ugi and Passerini reactions. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, agrochemical development, and materials science for creating novel compounds with tailored properties.

Application

• Pharmaceutical Intermediates: A key synthon for constructing diverse nitrogen-containing heterocycles and peptidomimetics in drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Employed in the synthesis of functional polymers, ligands for catalysis, and advanced organic frameworks.
• Medicinal Chemistry: Facilitates the rapid assembly of compound libraries for high-throughput screening against biological targets.
• Chemical Biology: Serves as a probe or tag in bioconjugation chemistry due to the unique reactivity of the isocyanide group.
• Catalyst & Ligand Development: Acts as a precursor for specialized ligands used in transition metal catalysis.

Basic Information

Product Name	4-Fluorophenyl Isocyanide
CAS No.	24075-34-1
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	1-Fluoro-4-isocyanobenzene; p-Fluorophenyl isocyanide; 4-Fluorobenzene isocyanide; 4-Fluorophenyl isonitrile; Isocyanic acid, 4-fluorophenyl ester; 4-Fluorophenylisonitrile; (4-Fluorophenyl)isocyanide
EINECS	Contact for details

Quality Control

Our 4-Fluorophenyl Isocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; handle and store accordingly to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.