Description

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe Acetate Salt is a synthetic peptide sequence, also known as Bradykinin (1-8), with the CAS registry number 23827-91-0. This compound is a key fragment of the endogenous vasoactive peptide bradykinin, making it a critical tool for biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular, inflammation, and pain pathway studies. The acetate salt form enhances the peptide's stability and solubility for experimental use.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the kallikrein-kinin system, blood pressure regulation, and vascular permeability.
• Pharmacology Screening: Serves as a ligand for characterizing and validating bradykinin receptor subtypes (B1 and B2) in drug discovery programs.
• Inflammation Models: Applied in in vitro and in vivo models to induce and study inflammatory responses and edema.
• Peptide Chemistry: Acts as a building block or intermediate for the synthesis of longer, modified peptide analogs with tailored biological activities.
• Diagnostic Development: Employed in the development of immunoassays (ELISA, RIA) for the detection and quantification of kinin-related biomarkers.
• Cell Signaling Studies: Utilized to investigate intracellular signaling pathways, including calcium mobilization and nitric oxide release, triggered by receptor activation.

Basic Information

Product Name	Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe Acetate Salt
CAS No.	23827-91-0
Molecular Formula	C44H64N14O11 • xC2H4O2
Molecular Weight	904.0 g/mol (free base)
Synonyms	Bradykinin (1-8); H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH acetate salt; Des-Arg9-Bradykinin acetate; RPPGFSPF acetate; Kallidin I acetate; [Des-Arg9]-BK acetate; BK (1-8) acetate
EINECS	Contact for details

Quality Control

Every batch of Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe Acetate Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis by HPLC, MS, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the results against stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	Reported on COA
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.