Description

H-D-Glu(Ome)-Otbu·Hcl is a protected derivative of the amino acid glutamic acid, specifically engineered for peptide synthesis. This compound matters as a critical chiral building block, offering high purity and defined stereochemistry essential for constructing complex bioactive peptides. It is primarily needed by pharmaceutical researchers, peptide manufacturers, and fine chemical suppliers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of glutamic acid with side-chain protection.
• Solution-Phase Peptide Chemistry: Used in the synthesis of peptide fragments and conjugates requiring specific protecting group strategies.
• Pharmaceutical Research: Serves as a building block for novel peptide-based drug candidates targeting various diseases.
• Bioconjugation: Facilitates the creation of peptide-protein or peptide-small molecule hybrids for diagnostic and therapeutic applications.
• Biochemical Probe Development: Used to synthesize labeled or modified peptides for studying biological mechanisms and enzyme interactions.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	H-D-Glu(Ome)-Otbu·Hcl
CAS No.	23736-76-7
Molecular Formula	C11H22ClNO5
Molecular Weight	283.75 g/mol
Synonyms	H-D-Glu(OMe)-OtBu hydrochloride; D-Glutamic acid 1-methyl ester 5-(1,1-dimethylethyl) ester hydrochloride; (R)-2-Amino-5-(tert-butoxy)-5-oxopentanoic acid methyl ester hydrochloride; Boc-D-Glu(OMe)-OtBu·HCl (common mis-assignment); Fmoc-D-Glu(OtBu)-OH related derivative; D-Glutamic acid γ-methyl ester α-tert-butyl ester hydrochloride; Protected D-Glutamate derivative
EINECS	Contact for details

Quality Control

Our H-D-Glu(Ome)-Otbu·Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.