Description

6,11-Dihydro-N,n-Dimethyldibenzo(B,E)Thiepin-11-Propylamine 5,5-Dioxid E Fumarate is a high-purity organic compound, specifically the fumarate salt of a dibenzothiepin derivative, valued for its role as a key pharmaceutical intermediate. Its primary commercial significance lies in enabling the synthesis of advanced active pharmaceutical ingredients (APIs) with precise pharmacological profiles. This compound is essential for research institutions and manufacturers in the pharmaceutical and fine chemical sectors developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of proprietary active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical and research settings for developing compounds targeting the central nervous system.
• Fine Chemical Synthesis: Serves as a specialized precursor in multi-step organic synthesis for complex molecule construction.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP production campaigns.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	6,11-Dihydro-N,n-Dimethyldibenzo(B,E)Thiepin-11-Propylamine 5,5-Dioxid E Fumarate
CAS No.	23735-20-8
Molecular Formula	C23H27NO4S
Molecular Weight	413.53 g/mol
Synonyms	Doxepin Fumarate; Doxepin Hydrochloride Related Compound E (Fumarate); 11-(3-(Dimethylamino)propyl)-6,11-dihydrodibenzo[b,e]thiepin 5,5-dioxide fumarate; NSC 108164; Dibenzo[b,e]thiepin-11(6H)-one, 11-[3-(dimethylamino)propyl]-6,11-dihydro-, 5,5-dioxide, (2E)-2-butenedioate (1:1); Doxepin Impurity F (Fumarate); 3-(Dimethylamino)propyliden-6,11-dihydrodibenzo[b,e]thiepin-11-ol 5,5-dioxide fumarate.
EINECS	Contact for details

Quality Control

Our 6,11-Dihydro-N,n-Dimethyldibenzo(B,E)Thiepin-11-Propylamine 5,5-Dioxid E Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.