Description

Tris(Hexahydro-1H-Azepin-1-Yl)Phosphine CAS NO 23720-18-5 is a specialized organophosphorus compound featuring a tertiary phosphine core ligated by three hexahydroazepine (homopiperidine) groups. This structure makes it a highly effective and versatile ligand for transition metal catalysis, particularly in cross-coupling reactions and hydrogenation processes. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to develop novel synthetic routes and optimize production efficiency.

Application

• As a ligand in homogeneous catalysis for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi).
• As a key component in catalyst systems for hydrogenation and hydroformylation of fine chemicals.
• In academic and industrial R&D for developing new synthetic methodologies in organic chemistry.
• For the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
• In the production of agrochemicals and specialty chemicals requiring precise metal-ligand complexes.
• As a precursor for advanced material synthesis, including metal-organic frameworks (MOFs) and polymers.

Basic Information

Product Name	Tris(Hexahydro-1H-Azepin-1-Yl)Phosphine
CAS No.	23720-18-5
Molecular Formula	C18H36N3P
Molecular Weight	325.47 g/mol
Synonyms	Tris(homopiperidino)phosphine; Tris(hexamethyleneimino)phosphine; Phosphorous triamide, N,N',N''-tris(hexahydro-1H-azepin-1-yl)-; 1,1',1''-Phosphinidynetris(hexahydro-1H-azepine); Tris(perhydroazepin-1-yl)phosphine; THAP; Homopiperidine phosphine ligand
EINECS	Contact for details

Quality Control

Our Tris(Hexahydro-1H-Azepin-1-Yl)Phosphine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high purity and consistent performance as a ligand. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. Keep the container in a cool, dry, well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR	Conforms to reference
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.