Description

Rac Mepindolol-D7 CAS NO 23694-81-7 is a deuterated isotopologue of the β-adrenergic receptor antagonist mepindolol, where seven hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative bioanalysis of mepindolol and related compounds in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based assays to study the absorption, distribution, metabolism, and excretion (ADME) profile of mepindolol.
• Pharmacological Research: Enables precise quantification in studies investigating β-blocker activity, receptor binding assays, and cardiovascular research.
• Clinical Trial Support: Provides method validation and sample analysis support for clinical studies involving mepindolol.
• Forensic and Toxicological Analysis: Facilitates accurate detection and quantification of mepindolol in forensic investigations.
• Method Development and Validation: Aids analytical chemists in developing robust, sensitive, and specific LC-MS/MS methods compliant with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Rac Mepindolol-D7
CAS No.	23694-81-7
Molecular Formula	C15H15D7N2O2
Molecular Weight	265.38 g/mol (approx.)
Synonyms	Mepindolol-d7; (±)-Mepindolol-d7; 1-(Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol-d7; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-1H-indole-d7; 4-[2-Hydroxy-3-(isopropylamino)propoxy]indole-d7; Corindolan-d7
EINECS	Contact for details

Quality Control

Our Rac Mepindolol-D7 is manufactured under strict quality control protocols to ensure it meets the exacting requirements for isotopic purity and chemical purity necessary for analytical applications. Each batch is characterized using advanced techniques including NMR, HPLC, and high-resolution mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirming structural identity. We support compliance with cGMP and ICH guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.